PAN is psychotropic analgesic nitrous oxide. PAN has been used, mainly in dentistry, for over sixty years for its analgesic (pain relieving) and anxiolytic (anxiety nullifying) rather than its anaesthetic properties. In medical practice, although often used as an anaesthetic it is also used as an analgesic during child birth, while the patient is fully conscious. At psychotropic analgesic concentrations, the patient is always conscious, thus avoiding the necessity of using expensive monitoring devices which are almost always needed during anaesthesia. At the relatively low concentrations consistent with PAN, nitrous oxide interacts with the endogenous opioid (endorphin) system in man and so yields it psychotropic actions. As we are now aware, in common with other opioids (e.g. morphine and pethidine), PAN also interacts with other neurotransmitters apart from the endorphins. Neurotransmitters are chemical messengers that are involved in transmitting neural messages from nerve to nerve. Because PAN is administered as a gas, and breathed into the lungs it is speedily absorbed and reaches the brain within seconds. As a result it produces almost immediate noticeable changes. When the administration of PAN ceases the off-set of action is as rapid, because it leaves the body so briskly. The rapid onset and offset of PAN and its actions on the endorphin system enables the investigator to finely adjust the endorphin system in healthy as well as ill people. As a result, PAN has given scientists working at SABRI a substantial lead over other researchers in investigating brain function directly in people. In short, it obviates almost all animal experimentation. The safe and most effective application of PAN is through the customised and commercially available dental equipment (Matrx by Porter MDM Quantiflex, or similar commercially available dental analgesia machine). The latter equipment guarantees that at least 30% oxygen is administered to the patient at all times. It also has an attachment that reduces nitrous oxide levels to those compatible with ruling health standards. It also encompasses a fail-safe device which if the flow of oxygen ever fall below 30% the nitrous oxide stream is instantly halted. As a result, the chance of delivering a mixture without a safe level of oxygen is avoided as well as the possibility of anaesthesia.
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